The Jon Moulton Charity Trust
Background
The Charity Trust was set up in 2018 to continue the work of the previous charity (the J P Moulton Charitable Foundation). To date (July 2026) some £56 million has been committed to clinical trials by Jon Moulton CBE and these vehicles.
Principal Aim
To fund non-commercial clinical trials with the aim to make clinical advances and promote the relief of suffering (main activity).
Clinical Research Awards
Since their inception, the charities have funded over 180 clinical trials which have been selected based on high quality science with the potential to have a direct benefit to patients. The trials have been conducted in a wide range of therapy areas including respiratory, women’s health, oncology, cardiovascular, diabetes, multiple sclerosis, several rare diseases, COPD, paediatrics, COVID-19 and the funded trials are usually interventional.
The charities have supported ground-breaking research in diseases that struggle to obtain funding from other funders as they do not fulfil their funding criteria e.g. head and neck cancer and rare diseases. The Foundation and Charity Trust have also entered into several joint ventures with other medical charities to help support larger trials.
How to Apply for Funding
Calls for funding are advertised in the Lancet and BMJ periodically.
Successful applications will be funded by The Jon Moulton Charity Trust.
Applications should initially be no more than 12 pages in length and they should outline the following:-
- Research title
- Contact details for the lead applicant
- The background and rationale for the trial
- The expertise and experience of the applicants
- A summary protocol including details of any devices, investigational medicinal products and statistical calculations
- A detailed budget and justification of costs
- A firm timescale for the duration of the trial – including realistic set-up, recruitment and analysis periods
- Any ethical or conflicts of interest issues
- Possible and desired outcomes
- Applicants will receive a decision approximately 6 weeks (often quicker) after the submission deadline.
- Awardees will be expected to provide a final budget with calendarisation of expenditure
- Progress reports are required every quarter
Confirmation in writing to the Trustees that:-
- All findings from your trials will be made available for publication and efforts will be made for publication.
- No intellectual property generated from the trial will be retained for commercial exploitation other than with the prior written consent of the Trustees.
Approximately 20% of applications receive full or partial funding and the charities have provided over £52 million in funding since 2004. Researchers have published well over 100 articles as a direct result of the funding awarded by the Foundation and Charity Trust.
Funding Calls
The Jon Moulton Charity Trust’s last funding call for clinical trial applications was in 2019 Over 100 applications covering some £60 million were received by the closing date of 20th December. Many of these applications were of exceptional quality and the overall standard high. The Trustees have now agreed to provide in excess of £14 million to fund 27 of these trials which cover a wide spread of therapy areas.
Please note that the funding calls are not annual, and we hope to announce the next funding soon.
Publications
Examples of publications resulting from funding can be accessed below:-
A multicentre randomized controlled trial of transabdoninal verus transvaginal cervical cerclage - read more
Does the addition of subcutaneous interferon-alpha 2b for 6 months only to the treatment of Behcet's disease significantly reduce the number of patients requiring immunosuppressive agents to control their disease over the following 2 years - read more
Randomised, placebo-controlled trial of itraconazole in the treatment of Fungal-sensitised patients with severe asthma without ABPA - read more and read more
A pilot study of combination monoclonal antibody treatment in early active relapsing-remitting multiple sclerosis using Campath-1H and its non-binding form, SM3 - read more
Gastro-oesophageal reflux disease in chronic cough: a randomised control trial of medical versus surgical treatments - read more and read more and read more
A randomised trial of botulinum toxin A versus placebo for refractory detrusor over-activity - RELAX study - read more
AZALEP a randomized controlled trial of azathioprine to treat leprosy nerve damage and Type 1 reactions in India - read more
Phase II trial of autologous dentritic cells transfected with a plasmid encoding melanocyte differentiation antigens using a non-viral delivery system for the treatment of patients with metastatic melanoma - read more
The effect of thalidomide on cachexia in upper gastrointestinal cancer - read more
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients - read more
The role of minimally invasive surgery in unborn babies with lower urinary tract obstruction - read more
Cranberry product versus low does trimethoprim in the prevention of recurrent urinary infections in older women - read more
Does remote ischaemic preconditioning reduce complications following major vascular surgery - read more
Repair of Spinal Root Injury by Transplantation of Autologous Adult Olfactory Ensheathing Cells - read more
Atorvastatin for preventing the progression of sepsis to severe sepsis (ASEPSIS Trial): a randomised, double-blind, placebo-controlled trial - read more
A phase I/II clinical study of gene modified donor lymphocytes following haploidentical haematopoietic stem cell transplantation - read more
Investigation of Simvastatin in Secondary Progressive Multiple Sclerosis (MS-STAT) - read more
Genetic factors and gene-environment interactions in the onset, persistence and severity of asthma - read more - read more
The Epistasis Project - read more and read more and read more and read more
Scavenging free haemoglobin attenuates the systemic inflammation response following surgery - read more
Comparison of high flow versus titrated oxygen therapy in the emergency department management of St Elevation Myocardial Infarction Trial - OPTIMISE study - read more
Cognitive function and surgical success following pulmonary endarterectomy - The PEACOG trial - read more
Vitamin D and skeletal muscle weakness in chronic obstructive pulmonary disease - read more
Superdose project - a community study investigating a dose relationship between neonatal BCG vaccination and risk of asthma and atopy in children - MANCAS Study - read more
A randomised controlled trial of laparoscopic adhesiolysis on chronic pelvic pain - read more
A randomised controlled trial of prednisolone for women with recurrent miscarriage and high levels of uNK cells in the endometrium - read more
Muscle MRI in Congenital Myasthenia - read more
Lenviral Gene Therapy for inherited skin disease: Phase 1 testing of ex-vivo gene modified skin grafts in Netherton Syndrome - read more and read more
Is diabetes surgery effective and safe for the treatment of Type 2 Diabetes Mellitus? - read more and read more and read more and read more and read more and read more
Susceptibility to infections and exacerbations of asthma: makers and mechanisms - read more
Avoiding mite allergen to prevent asthma exacerbations in children - read more
Duration of Luteal Support with progesterone pessaries to improve success rates in assisted conception; a randomised controlled trial. (The DOLS Trial) - read more
Production and First-in-Man Use of T Cells Engineered to Express a HSVTK-CD34 Sort-Suicide Gene - read more
A multicentre randomized controlled trial of transabdoninal verus transvaginal cervical cerclage - read more
Cough responses to novel tussive agents in health and disease - read more and read more and read more and read more and read more and read more and read more
CRASH 3 - read more
Defining defective acetylcholine receptor function for definitive diagnosis and appropriate treatments of congenital myasthenic syndromes - read more and read more and read more and read more
Reducing brain injury in babies by combining cooling therapy and xenon gas - read more
Immunotherapy with CD19ζ gene-modified EBV-specific CTLs after stem cell transplant in children with high-risk acute lymphoblastic leukaemia - read more
Promoting thymic rescue of lymphopenia in humans - read more
Treatment of Premature Ovarian Failure - read more
A pilot comparison of bladder awareness during filling and changes in sensation in white and Indian Asian Women - read more
Genes, mechanisms, models and treatments for myasthenia - read more
A study to investigate circadian biology of asthma - read more
Phase IIa, randomised, open label, controlled trial of rostuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis PROteKT - read more
Dietary nitrate supplementation to enhance pulmonary rehabilitation in chronic obstructive pulmonary disease - read more and read more
Randomised Controlled Trial of Intermittent vs. Continuous Feeding on Skeletal Muscle Wasting During Early Critical Illness - read more
GLP-1 Receptor Agonist interVention for poor responders after barIAtric Surgery - read more
Simvastatin as a neuroprotective treatment for Parkinson’s disease – a double-blind, placebo controlled clinical learning study in patients of moderate severity. Part of The Cure Parkinson's Trust's linked clinical trials initiative - read more
A randomised, controlled, pilot study examining neurally-adjusted ventilatory assist (NAVA) in at high risk of prolonged ventilatory failure during recovery from critical illness - read more and read more
A pilot trial for McArdle disease - read more
Safety and feasibility of a clinical trial of permissive hypoxia in paediatric critical illness - read more
INvestigating the lowest Threshold of vascular bENefits from LDL cholesterolcholesterol lowering with a PCSK9 mAb InhibiTor (alirocumab) in healthY volunteers and patients with stable cardiovascular disease (INTENSITY) - read more
The pathology of T cells in immune thrombocytopenia.- read more and read more
Algorithmic Protamine Dosing for Reversal of Heparin after Cardiopulmonary Bypass – The PRODOSE Trial) - Trial Complete. Publication submitted to American Heart Association: Circulation - read more
NeuroSAFE: A single-blinded, multi-centre randomised controlled trial comparing NeuroSAFE Robotic assisted radical prostatectomy (RALP) to standard RALP..- read more and read more
A “decoy bypass” for treatment of obesity and diabetes - read more
Vascularised sentinel skin flaps to detectrejection in lung and heart transplantation - read more and read more and read more and read more
Developing Tests for Endometrial Cancer detection (DETECT): protocol for a diagnostic accuracy study of urine and vaginal samples for the detection of endometrial cancer by cytology in women with postmenopausal bleeding- read more
Pharmacokinetics of intramuscular tranexamic acid in trauma patients: a clinical trial- read more
Maintaining Fitness during neoadjuvant Chemotherapy for oesophageal cancer: a feasibility study to investigate the utility of a simple, home–based, exercise intervention during chemotherapy.- read more
Breath and plasma metabolomics to assess inflammation in acute stroke - read more
Clinical trial to detect and rule out significant prostate cancer - Multiparametric ultrasound versus multiparametric MRI to diagnose prostate cancer (CADMUS): a prospective, multicentre, paired-cohort, confirmatory study - read more
Using INFOrmation Videos to Improve Patients’ satisfaction and experience in Endoscopy (INFOVIPE): Randomised Controlled Trial - read more
A Phase I Clinical study to assess the safety and immunogenicity of a self-amplifying RNA (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID19 - read more read more
The pathology of T cells in immune thrombocytopenia - read more read more
Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study - read more
A Double-Blind, Randomised, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease - read more
Interim analysis of the T4 immunotherapy study - read more
A precision medicine study to evaluate single nucleotide polymorphisms in the ET-1 pathway and other factors that maximise ET-1 receptor antagonist responses in microvascular angina - read more and read more and read more and read more
Cardiac MRI in the assessment of chronic thromboembolic pulmonary hypertension and response to treatment - read more
Interim toxicity analysis from the randomised HERMES trial of 2- and 5- fraction magnetic resonance imaging - guided adaptive prostate radiation therapy - read more read more
Mental Imagery to Reduce Alcohol-related harm in patients with alcohol use disorder and alcohol-related liver damaGE: the MIRAGE randomised pilot trial results - read more
Repeat placental growth factor-based testing in women with suspected preterm pre-eclampsia (PARROT-2): a multicentre, parallel-group, superiorty, randomised controlled trial - read more
IgE-sensitization predicts threshold but not anaphylaxis during oral food challenges to cow's milk - read more
Standard and Hypofractionated Dose Escalation to Intraprostatic Tumor Nodules in Localized Prostate Cancer: 5-Year Efficacy and Toxicity in the DELINEATE Trial - read more
Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial - read more
Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study - read more
Bariatric Surgery in Women with Polycystic Ovary Syndrome - read more
Bariatric surgery for spontaneous ovulation in women living with polycystic ovary syndrome: the BAMBINI multicentre, open-label, randomised controlled trial - read more
Progenitor cell-derived basophils: A novel barcoded passive degranulation assay in allergic diseases - read more
Basophil Activating Factors in the Serum May Underlie the ‘Nonreleaser’ Basophil Status in the Basophil Activation Test - read more
GABA and Glutamate in hMT+ Link to Individual Differences in Residual Visual Function After Occipital Stroke - read more
Clinical phenotypes of depressed patients with evidence of inflammation and somatic symptoms - read more
Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms - read more
Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial— The ABC-Sepsis Trial*- read more
Decellularized dermis allograft for the treatment of venous leg ulceration: the DAVE RCT - read more
Mexiletine versus lamotrigine in non-dystrophic myotonias: a randomised, double-blind, head-to-head, crossover, non-inferiority, phase 3 trial - read more
Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial - read more
Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial - read more
The impact of dosage timing for inhaled corticosteroids in asthma: a randomised three-way crossover trial - read more
MicroRNAs as Bile-based biomarkers in pancreaticobiliary cancers (MIRABILE): a cohort study - read more
A novel dietary therapy to control recurrence of gut inflammation in children with Crohn’s disease in remission iPENS - read more and read more and read more
VaccAir: Understanding the utility of unmanned aerial vehicles (UAVs) in critical vaccine supply chains - read more
Intelligent deep brain stimulation for Parkinson’s disease - read more and read more
Quality of Life After Cardiac Surgery: The QUACS Study and Benefit Prediction Model - read more
Contact Details
For any enquiries please contact Helen Critchley via email:- helen@jmcharitytrust.gg
The Jon Moulton Charity Trust is registered in Guernsey with registered Charity number CH605 and has its registered address at Fourth Floor, Plaza House, Admiral Park, St Peter Port, Guernsey, GY1 2HU